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Relaxin family peptide hormones : ウィキペディア英語版 | Relaxin family peptide hormones
Relaxin family peptide hormones in humans are represented by 7 members: three relaxin-like (RLN) and four insulin-like (INSL) peptides. This subdivision into 2 classes (RLN and INSL) is based primarily on early findings, and does not reflect the evolutionary origins or physiological differences between peptides.〔 For example, it is known that the genes coding for RLN3 and INSL5 arose from one ancestral gene, and INSL3 shares origin with RLN2 and its multiple duplicates (e.g. RLN1, INSL4, INSL6). ==Genetics== In humans and many other tetrapods, the RLN/INSL-encoding genes exist in 4 distinct clusters. The largest cluster contains 4 loci: RLN1, RLN2, INSL4 and INSL6, situated in tandem on human chromosome 9 (chromosome 9). This cluster arose from multiple local gene duplications that took place in the ancestor of placental mammals. The other three RLN/INSL genes exist as single loci in two linkage groups: RLN3 (chromosome 19), INSL3 (chromosome 19, 3.8 Mb apart from RLN3) and INSL5 (chromosome 1).
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